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Friday, March 1, 2013

Plasma Enzymes

Dr. Abir Alghanouchi Biochemistry department Sciences college

There are 2 types of  germ plasm enzymes:
1.

available  germ plasm enzymes Non functional plasma enzyme in tissues

2.

Functional plasma enzymes
Present in plasma in normal individuals  both the time Their  substrate are also present in the plasma
o Lipoprotein lipase: hydrolyzes chylomicrons o Pseudocholinesterase: hydrolyzes the acetylcholine

Synthesized in tissues but their  density in  crinkle  may be equal or  high than that in tissues

Non functional plasma enzymes
Normally, they are at a very low concentration in  plasma compared to their concentration in tissues

They have no physiological functions in blood,  substrate usually absent from plasma and appear  incidentally in the blood        

Non functional plasma enzymes
Increased levels of non functional plasma enzymes in  plasma indicates tissue damage

These enzymes can be  employ for diagnosis

Non functional plasma enzymes
Creatine kinase Lactate dehydrogenase Transaminase

Acid phosphatase

Amylase

alkalic phosphatase

It is an enzyme that catalyzes a type of reaction between  an amino  loony toons and an ??keto acid. There are 2 important transaminases which are  widely  used for diagnosis: 
1. 2.

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Aspartate transaminase (AST) Alanine transaminase (ALT)

Found in all tissues especially heart, liver and skeletal muscles It facilitates the conversion of:
AST

Aspartate + ? ketoglutarate                glutamate+oxaloacetate

AST natural process     in myocardial infarction     maximum level is  reached 2 days after the infarction

Two isoenzymes are present in humans, they have high  similarity 1. GOT1: the cytosolic isoenzyme derives  in general from red blood cells and heart 2. GOT2: the mitochondrial isoenzyme is predominantly  present in liver

Present mainly in liver an to a less extend in kidney and  skeletal muscles, so it is most specific for liver It catalyzes the  head of an amino group from...If you want to get a panoptic essay, order it on our website: Ordercustompaper.com



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